InterSCOPE Study: Associations Between Esophageal Squamous Cell Carcinoma and Human Papillomavirus Serological Markers
Identifieur interne : 005B32 ( Main/Exploration ); précédent : 005B31; suivant : 005B33InterSCOPE Study: Associations Between Esophageal Squamous Cell Carcinoma and Human Papillomavirus Serological Markers
Auteurs : Freddy Sitas [Australie] ; Sam Egger [Australie] ; Margaret I. Urban [Afrique du Sud] ; Philip R. Taylor [États-Unis] ; Christian C. Abnet [États-Unis] ; Paolo Boffetta [États-Unis, France] ; Dianne L. O'Connell [Australie] ; David C. Whiteman [Australie] ; Paul Brennan [France] ; Reza Malekzadeh [Iran] ; Michael Pawlita [Allemagne] ; Sanford M. Dawsey [États-Unis] ; Tim Waterboer [Allemagne] ; Penelope M. Webb ; Adèle C. Green ; Nicholas K. Hayward ; David Zaridze ; Ivana Holcatova ; Dana Mates ; Neonila Szeszenia-Dabrowska ; Gilles Ferro ; Vladimir Janout ; Maria Paula Curado ; Ana Maria Menezes ; Sergio Koifman ; Farhad Islami ; Dariush Nasrollahzadeh ; NAN HU ; Alisa M. Goldstein ; YING GAO ; TI DING ; Farin KamangarSource :
- Journal of the National Cancer Institute [ 0027-8874 ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Background The role of human papillomavirus (HPV) in the causation of esophageal squamous cell carcinoma is unclear. We examined the associations between esophageal squamous cell carcinoma and 28 centrally measured HPV serological markers in serum from six existing case-control studies conducted in regions with differing background risks of esophageal cancer. Methods We used centralized multiplex serology to test serum samples from 1561 case subjects and 2502 control subjects from six case-control studies for antibodies to the major HPV capsid protein (L1) and/or the early proteins E6 and/or E7 of eight high-risk, two low-risk, and four cutaneous HPV types. Study-specific odds ratios (ORs) and corresponding 95% confidence intervals (Cls) were estimated using conditional logistic regression with adjustment for smoking, alcohol consumption, and other potential confounders. Pooled odds ratios and 95% confidence intervals were calculated using either a linear mixed-effects approach or a joint fixed-effects approach. All statistical tests were two-sided. Results We found statistically significant associations between esophageal squamous cell carcinoma and antibodies to E6 for HPV16 (OR = 1.89, 95% CI = 1.09 to 3.29, P= .023) and HPV6 (OR = 2.53, 95% CI = 1.51 to 4.25, P< .001) but not for other tested HPV types. There were no statistically significant associations between esophageal squamous cell carcinoma and antibodies to E7 for any of the tested HPV types. Simultaneous seropositivity for HPV16 E6 and E7 was rare (four case subjects, two control subjects; OR = 5.57, 95% CI = 0.90 to 34.35; P= .064). We also found statistically significant associations between esophageal squamous cell carcinoma and capsid antibodies for the high-risk mucosal type HPV33 L1 (OR = 1.30, 95% CI = 1.00 to 1.69; P=.047) and the low-risk mucosal types HPV6 (OR = 1.22, 95% CI = 1.05 to 1.42; P= .010) and HPV11 (OR = 1.30, 95% CI = 1.09 to 1.56, P = .0036). Conclusions We found limited serological evidence of an association between esophageal squamous cell carcinoma and HPV in the populations studied. Although HPV does not appear to be an important risk factor for esophageal squamous cell carcinoma, we cannot exclude the possibility that certain HPV types may be involved in a small subset of cancers.
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Affiliations:
- Afrique du Sud, Allemagne, Australie, France, Iran, États-Unis
- Auvergne-Rhône-Alpes, Bade-Wurtemberg, District de Karlsruhe, Gauteng, Rhône-Alpes
- Heidelberg, Johannesbourg, Lyon
- Université du Witwatersrand
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Urban</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>NHLS/MRC Cancer Epidemiology Research Group, National Health Laboratory Service</s1><s2>Johannesburg</s2><s3>ZAF</s3><sZ>3 aut.</sZ></inist:fA14><country>Afrique du Sud</country><wicri:noRegion>Johannesburg</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>University of the Witwatersrand</s1><s2>Johannesburg</s2><s3>ZAF</s3><sZ>3 aut.</sZ></inist:fA14><country>Afrique du Sud</country><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName><orgName type="university">Université du Witwatersrand</orgName></affiliation></author><author><name sortKey="Taylor, Philip R" sort="Taylor, Philip R" uniqKey="Taylor P" first="Philip R." last="Taylor">Philip R. Taylor</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Division of Cancer Epidemiology and Genetics, US National Cancer Institute</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, MD</wicri:noRegion></affiliation></author><author><name sortKey="Abnet, Christian C" sort="Abnet, Christian C" uniqKey="Abnet C" first="Christian C." last="Abnet">Christian C. Abnet</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Division of Cancer Epidemiology and Genetics, US National Cancer Institute</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, MD</wicri:noRegion></affiliation></author><author><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>The Tisch Cancer Institute, Mount Sinai School of Medicine</s1><s2>New York, NY</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>International Prevention Research Institute</s1><s2>Lyon</s2><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="O Connell, Dianne L" sort="O Connell, Dianne L" uniqKey="O Connell D" first="Dianne L." last="O'Connell">Dianne L. O'Connell</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cancer Council NSW, Cancer Epidemiology Research Unit</s1><s2>Sydney, NSW</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW</wicri:noRegion></affiliation></author><author><name sortKey="Whiteman, David C" sort="Whiteman, David C" uniqKey="Whiteman D" first="David C." last="Whiteman">David C. Whiteman</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Population Health Department, Queensland Institute of Medical Research</s1><s2>Brisbane, QLD</s2><s3>AUS</s3><sZ>8 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, QLD</wicri:noRegion></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>International Agency for Research on Cancer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Malekzadeh, Reza" sort="Malekzadeh, Reza" uniqKey="Malekzadeh R" first="Reza" last="Malekzadeh">Reza Malekzadeh</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Digestive Disease Research Center, Tehran University of Medical Sciences</s1><s2>Tehran</s2><s3>IRN</s3><sZ>10 aut.</sZ></inist:fA14><country>Iran</country><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Pawlita, Michael" sort="Pawlita, Michael" uniqKey="Pawlita M" first="Michael" last="Pawlita">Michael Pawlita</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Genome Modifications and Carcinogenesis Division, Infection and Cancer Program, German Cancer Research Center</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Dawsey, Sanford M" sort="Dawsey, Sanford M" uniqKey="Dawsey S" first="Sanford M." last="Dawsey">Sanford M. Dawsey</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Division of Cancer Epidemiology and Genetics, US National Cancer Institute</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, MD</wicri:noRegion></affiliation></author><author><name sortKey="Waterboer, Tim" sort="Waterboer, Tim" uniqKey="Waterboer T" first="Tim" last="Waterboer">Tim Waterboer</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Genome Modifications and Carcinogenesis Division, Infection and Cancer Program, German Cancer Research Center</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Webb, Penelope M" sort="Webb, Penelope M" uniqKey="Webb P" first="Penelope M." last="Webb">Penelope M. Webb</name></author><author><name sortKey="Green, Adele C" sort="Green, Adele C" uniqKey="Green A" first="Adèle C." last="Green">Adèle C. Green</name></author><author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name></author><author><name sortKey="Zaridze, David" sort="Zaridze, David" uniqKey="Zaridze D" first="David" last="Zaridze">David Zaridze</name></author><author><name sortKey="Holcatova, Ivana" sort="Holcatova, Ivana" uniqKey="Holcatova I" first="Ivana" last="Holcatova">Ivana Holcatova</name></author><author><name sortKey="Mates, Dana" sort="Mates, Dana" uniqKey="Mates D" first="Dana" last="Mates">Dana Mates</name></author><author><name sortKey="Szeszenia Dabrowska, Neonila" sort="Szeszenia Dabrowska, Neonila" uniqKey="Szeszenia Dabrowska N" first="Neonila" last="Szeszenia-Dabrowska">Neonila Szeszenia-Dabrowska</name></author><author><name sortKey="Ferro, Gilles" sort="Ferro, Gilles" uniqKey="Ferro G" first="Gilles" last="Ferro">Gilles Ferro</name></author><author><name sortKey="Janout, Vladimir" sort="Janout, Vladimir" uniqKey="Janout V" first="Vladimir" last="Janout">Vladimir Janout</name></author><author><name sortKey="Curado, Maria Paula" sort="Curado, Maria Paula" uniqKey="Curado M" first="Maria Paula" last="Curado">Maria Paula Curado</name></author><author><name sortKey="Menezes, Ana Maria" sort="Menezes, Ana Maria" uniqKey="Menezes A" first="Ana Maria" last="Menezes">Ana Maria Menezes</name></author><author><name sortKey="Koifman, Sergio" sort="Koifman, Sergio" uniqKey="Koifman S" first="Sergio" last="Koifman">Sergio Koifman</name></author><author><name sortKey="Islami, Farhad" sort="Islami, Farhad" uniqKey="Islami F" first="Farhad" last="Islami">Farhad Islami</name></author><author><name sortKey="Nasrollahzadeh, Dariush" sort="Nasrollahzadeh, Dariush" uniqKey="Nasrollahzadeh D" first="Dariush" last="Nasrollahzadeh">Dariush Nasrollahzadeh</name></author><author><name sortKey="Nan Hu" sort="Nan Hu" uniqKey="Nan Hu" last="Nan Hu">NAN HU</name></author><author><name sortKey="Goldstein, Alisa M" sort="Goldstein, Alisa M" uniqKey="Goldstein A" first="Alisa M." last="Goldstein">Alisa M. Goldstein</name></author><author><name sortKey="Ying Gao" sort="Ying Gao" uniqKey="Ying Gao" last="Ying Gao">YING GAO</name></author><author><name sortKey="Ti Ding" sort="Ti Ding" uniqKey="Ti Ding" last="Ti Ding">TI DING</name></author><author><name sortKey="Kamangar, Farin" sort="Kamangar, Farin" uniqKey="Kamangar F" first="Farin" last="Kamangar">Farin Kamangar</name></author></analytic><series><title level="j" type="main">Journal of the National Cancer Institute</title><title level="j" type="abbreviated">J. Natl. Cancer Inst.</title><idno type="ISSN">0027-8874</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of the National Cancer Institute</title><title level="j" type="abbreviated">J. Natl. Cancer Inst.</title><idno type="ISSN">0027-8874</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological marker</term><term>Cancerology</term><term>Carcinogenesis</term><term>Esophagus cancer</term><term>Esophagus squamous cell carcinoma</term><term>Human</term><term>Human papillomavirus</term><term>Serology</term><term>Viral disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Carcinome épidermoïde de l'oesophage</term><term>Papillomavirus humain</term><term>Virose</term><term>Cancer de l'oesophage</term><term>Marqueur biologique</term><term>Cancérologie</term><term>Carcinogenèse</term><term>Homme</term><term>Sérologie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background The role of human papillomavirus (HPV) in the causation of esophageal squamous cell carcinoma is unclear. We examined the associations between esophageal squamous cell carcinoma and 28 centrally measured HPV serological markers in serum from six existing case-control studies conducted in regions with differing background risks of esophageal cancer. Methods We used centralized multiplex serology to test serum samples from 1561 case subjects and 2502 control subjects from six case-control studies for antibodies to the major HPV capsid protein (L1) and/or the early proteins E6 and/or E7 of eight high-risk, two low-risk, and four cutaneous HPV types. Study-specific odds ratios (ORs) and corresponding 95% confidence intervals (Cls) were estimated using conditional logistic regression with adjustment for smoking, alcohol consumption, and other potential confounders. Pooled odds ratios and 95% confidence intervals were calculated using either a linear mixed-effects approach or a joint fixed-effects approach. All statistical tests were two-sided. Results We found statistically significant associations between esophageal squamous cell carcinoma and antibodies to E6 for HPV16 (OR = 1.89, 95% CI = 1.09 to 3.29, P= .023) and HPV6 (OR = 2.53, 95% CI = 1.51 to 4.25, P< .001) but not for other tested HPV types. There were no statistically significant associations between esophageal squamous cell carcinoma and antibodies to E7 for any of the tested HPV types. Simultaneous seropositivity for HPV16 E6 and E7 was rare (four case subjects, two control subjects; OR = 5.57, 95% CI = 0.90 to 34.35; P= .064). We also found statistically significant associations between esophageal squamous cell carcinoma and capsid antibodies for the high-risk mucosal type HPV33 L1 (OR = 1.30, 95% CI = 1.00 to 1.69; P=.047) and the low-risk mucosal types HPV6 (OR = 1.22, 95% CI = 1.05 to 1.42; P= .010) and HPV11 (OR = 1.30, 95% CI = 1.09 to 1.56, P = .0036). Conclusions We found limited serological evidence of an association between esophageal squamous cell carcinoma and HPV in the populations studied. Although HPV does not appear to be an important risk factor for esophageal squamous cell carcinoma, we cannot exclude the possibility that certain HPV types may be involved in a small subset of cancers.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Allemagne</li><li>Australie</li><li>France</li><li>Iran</li><li>États-Unis</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>District de Karlsruhe</li><li>Gauteng</li><li>Rhône-Alpes</li></region><settlement><li>Heidelberg</li><li>Johannesbourg</li><li>Lyon</li></settlement><orgName><li>Université du Witwatersrand</li></orgName></list><tree><noCountry><name sortKey="Curado, Maria Paula" sort="Curado, Maria Paula" uniqKey="Curado M" first="Maria Paula" last="Curado">Maria Paula Curado</name><name sortKey="Ferro, Gilles" sort="Ferro, Gilles" uniqKey="Ferro G" first="Gilles" last="Ferro">Gilles Ferro</name><name sortKey="Goldstein, Alisa M" sort="Goldstein, Alisa M" uniqKey="Goldstein A" first="Alisa M." last="Goldstein">Alisa M. Goldstein</name><name sortKey="Green, Adele C" sort="Green, Adele C" uniqKey="Green A" first="Adèle C." last="Green">Adèle C. Green</name><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name><name sortKey="Holcatova, Ivana" sort="Holcatova, Ivana" uniqKey="Holcatova I" first="Ivana" last="Holcatova">Ivana Holcatova</name><name sortKey="Islami, Farhad" sort="Islami, Farhad" uniqKey="Islami F" first="Farhad" last="Islami">Farhad Islami</name><name sortKey="Janout, Vladimir" sort="Janout, Vladimir" uniqKey="Janout V" first="Vladimir" last="Janout">Vladimir Janout</name><name sortKey="Kamangar, Farin" sort="Kamangar, Farin" uniqKey="Kamangar F" first="Farin" last="Kamangar">Farin Kamangar</name><name sortKey="Koifman, Sergio" sort="Koifman, Sergio" uniqKey="Koifman S" first="Sergio" last="Koifman">Sergio Koifman</name><name sortKey="Mates, Dana" sort="Mates, Dana" uniqKey="Mates D" first="Dana" last="Mates">Dana Mates</name><name sortKey="Menezes, Ana Maria" sort="Menezes, Ana Maria" uniqKey="Menezes A" first="Ana Maria" last="Menezes">Ana Maria Menezes</name><name sortKey="Nan Hu" sort="Nan Hu" uniqKey="Nan Hu" last="Nan Hu">NAN HU</name><name sortKey="Nasrollahzadeh, Dariush" sort="Nasrollahzadeh, Dariush" uniqKey="Nasrollahzadeh D" first="Dariush" last="Nasrollahzadeh">Dariush Nasrollahzadeh</name><name sortKey="Szeszenia Dabrowska, Neonila" sort="Szeszenia Dabrowska, Neonila" uniqKey="Szeszenia Dabrowska N" first="Neonila" last="Szeszenia-Dabrowska">Neonila Szeszenia-Dabrowska</name><name sortKey="Ti Ding" sort="Ti Ding" uniqKey="Ti Ding" last="Ti Ding">TI DING</name><name sortKey="Webb, Penelope M" sort="Webb, Penelope M" uniqKey="Webb P" first="Penelope M." last="Webb">Penelope M. Webb</name><name sortKey="Ying Gao" sort="Ying Gao" uniqKey="Ying Gao" last="Ying Gao">YING GAO</name><name sortKey="Zaridze, David" sort="Zaridze, David" uniqKey="Zaridze D" first="David" last="Zaridze">David Zaridze</name></noCountry><country name="Australie"><noRegion><name sortKey="Sitas, Freddy" sort="Sitas, Freddy" uniqKey="Sitas F" first="Freddy" last="Sitas">Freddy Sitas</name></noRegion><name sortKey="Egger, Sam" sort="Egger, Sam" uniqKey="Egger S" first="Sam" last="Egger">Sam Egger</name><name sortKey="O Connell, Dianne L" sort="O Connell, Dianne L" uniqKey="O Connell D" first="Dianne L." last="O'Connell">Dianne L. O'Connell</name><name sortKey="Whiteman, David C" sort="Whiteman, David C" uniqKey="Whiteman D" first="David C." last="Whiteman">David C. Whiteman</name></country><country name="Afrique du Sud"><noRegion><name sortKey="Urban, Margaret I" sort="Urban, Margaret I" uniqKey="Urban M" first="Margaret I." last="Urban">Margaret I. Urban</name></noRegion><name sortKey="Urban, Margaret I" sort="Urban, Margaret I" uniqKey="Urban M" first="Margaret I." last="Urban">Margaret I. Urban</name></country><country name="États-Unis"><noRegion><name sortKey="Taylor, Philip R" sort="Taylor, Philip R" uniqKey="Taylor P" first="Philip R." last="Taylor">Philip R. Taylor</name></noRegion><name sortKey="Abnet, Christian C" sort="Abnet, Christian C" uniqKey="Abnet C" first="Christian C." last="Abnet">Christian C. Abnet</name><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name><name sortKey="Dawsey, Sanford M" sort="Dawsey, Sanford M" uniqKey="Dawsey S" first="Sanford M." last="Dawsey">Sanford M. Dawsey</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name></region><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name></country><country name="Iran"><noRegion><name sortKey="Malekzadeh, Reza" sort="Malekzadeh, Reza" uniqKey="Malekzadeh R" first="Reza" last="Malekzadeh">Reza Malekzadeh</name></noRegion></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Pawlita, Michael" sort="Pawlita, Michael" uniqKey="Pawlita M" first="Michael" last="Pawlita">Michael Pawlita</name></region><name sortKey="Waterboer, Tim" sort="Waterboer, Tim" uniqKey="Waterboer T" first="Tim" last="Waterboer">Tim Waterboer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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